Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azacitidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 known ✓ | P26358 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 2/20 | 0.90 |
| ▸ | MTOR | P42345 | 2/20 | 0.90 |
| ▸ | TP53 | P04637 | 2/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.90 |
| ▸ | HTT | P42858 | 2/20 | 0.90 |
| ▸ | BLM | P54132 | 2/20 | 0.90 |
| ▸ | GMNN | O75496 | 1/20 | 0.90 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.90 |
| ▸ | THPO | P40225 | 1/20 | 0.90 |
| ▸ | RAB9A | P51151 | 1/20 | 0.90 |
| ▸ | HBB | P68871 | 1/20 | 0.90 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.90 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.59 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azacitidine SCHEMBL27819363 | 0.96 | LMNA (0.88) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL13376157 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL19060381 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL169369 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL18055593 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL23815524 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL7146234 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL16187746 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL2412035 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 | |
| Azacitidine SCHEMBL706302 | 0.95 | LMNA (1.00) | LMNAMTORTP53DNMT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011153374-A1 | PRODRUGS OF AZACITIDINE 5'-PHOSPHATE | SYNDAX PHARMACEUTICALS INC. (US) | 2011-12-08 | — | — | WO | disclosed |