Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.43 |
| ▸ | RAMP1 | O60894 | 13/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898117 | 0.86 | CALCRL (0.45) | CALCRLRAMP1 | |
| SCHEMBL1896082 | 0.73 | CALCRL (0.49) | CALCRLRAMP1 | |
| SCHEMBL16846524 | 0.70 | CALCRL (0.41) | CALCRLRAMP1 | |
| SCHEMBL13997603 | 0.68 | CALCRL (0.48) | CALCRLRAMP1 | |
| SCHEMBL13376820 | 0.67 | CALCRL (0.67) | CALCRLRAMP1 | |
| SCHEMBL16602196 | 0.66 | CALCRL (0.51) | CALCRLRAMP1 | |
| SCHEMBL16602192 | 0.66 | CALCRL (0.51) | CALCRLRAMP1 | |
| SCHEMBL16602178 | 0.66 | CALCRL (0.51) | CALCRLRAMP1 | |
| SCHEMBL1891441 | 0.66 | CALCRL (0.57) | CALCRLRAMP1 | |
| SCHEMBL22796647 | 0.64 | CALCRL (0.48) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091533-B1 | CONSTRAINED SPIROCYCLIC COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-11-28 | — | — | EP | disclosed |