Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 16/20 | 0.41 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.33 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13791578 | 0.83 | CALCRL (0.60) | CALCRLRAMP1PLD1CYP3A4 | |
| SCHEMBL3891344 | 0.75 | CALCRL (0.70) | CALCRLRAMP1PLD1CYP3A4 | |
| SCHEMBL5097854 | 0.75 | CALCRL (0.70) | CALCRLRAMP1PLD1CYP3A4 | |
| SCHEMBL31285887 | 0.70 | PLD1 (0.46) | CALCRLPLD1CYP3A4 | |
| SCHEMBL22605690 | 0.70 | PLD1 (0.46) | CALCRLPLD1CYP3A4 | |
| SCHEMBL16502185 | 0.70 | CALCRL (0.43) | CALCRLRAMP1 | |
| SCHEMBL3882130 | 0.69 | CALCRL (0.69) | CALCRLPLD1CYP3A4 | |
| SCHEMBL3887772 | 0.69 | CALCRL (0.70) | CALCRLRAMP1PLD1CYP3A4 | |
| SCHEMBL5091973 | 0.69 | CALCRL (0.70) | CALCRLRAMP1PLD1CYP3A4 | |
| SCHEMBL13792073 | 0.68 | CALCRL (0.70) | CALCRLRAMP1PLD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013214-B1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2015-06-24 | — | — | EP | disclosed |