Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pralidoxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pralidoxime SCHEMBL21981153 | 0.98 | ALDH1A1 (0.36) | ALDH1A1MAPTMEN1RAB9AKMT2A | |
| SCHEMBL20414330 | 0.72 | — | — | |
| SCHEMBL21990409 | 0.70 | — | — | |
| SCHEMBL21990407 | 0.70 | — | — | |
| SCHEMBL21267672 | 0.67 | MEN1 (0.40) | ALDH1A1MAPTMEN1RAB9AKMT2A | |
| SCHEMBL11575842 | 0.65 | MEN1 (0.42) | ALDH1A1MAPTMEN1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL31396653 | 0.63 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1RAB9AKMT2A | |
| SCHEMBL11103522 | 0.60 | ALDH1A1 (0.47) | ALDH1A1MAPTMEN1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL10697466 | 0.60 | ALDH1A1 (0.33) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL31379747 | 0.58 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116987025-B | Crystal form of pralidoxime chloride and preparation method thereof | 成都瑞尔医药科技有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |