Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17782347 | 0.88 | NR4A2 (0.62) | NR4A2GAATSHRL3MBTL1NPC1 | |
| SCHEMBL13431711 | 0.87 | NR4A2 (0.53) | NR4A2GAATSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL18832024 | 0.85 | ALDH1A1 (0.52) | NR4A2EGFRIGF1RSRCFLT4 | |
| SCHEMBL23551455 | 0.84 | NPC1 (0.42) | NR4A2GAAEGFRIGF1RSRC | |
| SCHEMBL18305477 | 0.82 | KMT2A (0.53) | NR4A2GAAEGFRIGF1RSRC | |
| SCHEMBL19522343 | 0.81 | KMT2A (0.42) | NR4A2GAAEGFRIGF1RSRC | |
| SCHEMBL23551453 | 0.80 | EGFR (0.42) | NR4A2GAAEGFRIGF1RSRC | |
| SCHEMBL4006680 | 0.79 | EGFR (0.44) | NR4A2GAAEGFRIGF1RSRC | |
| SCHEMBL23537996 | 0.78 | NR4A2 (0.44) | NR4A2GAATSHRL3MBTL1NPC1 | |
| SCHEMBL23538162 | 0.78 | TSHR (0.46) | NR4A2GAATSHRL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080660-B2 | Metal complex glycogen synthase kinase 3 inhibitors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080660-B2 | Metal complex glycogen synthase kinase 3 inhibitors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-12-20 | — | — | US | disclosed |