Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefmenoxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.97 |
| ▸ | PGR | P06401 | 3/20 | 0.97 |
| ▸ | PPARG | P37231 | 2/20 | 0.75 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.75 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.75 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.75 |
| ▸ | DAO | P14920 | 1/20 | 0.75 |
| ▸ | SNCA | P37840 | 1/20 | 0.75 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.75 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.74 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.67 |
| ▸ | APEX1 | P27695 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefmenoxime SCHEMBL192781 | 1.00 | NR1I2 (0.97) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL3252593 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL8768620 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL9659869 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL10492342 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL16072811 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL10633730 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL152861 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL1813696 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 | |
| Cefmenoxime SCHEMBL32668883 | 0.99 | NR1I2 (1.00) | NR1I2PGRPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797767-A1 | LEVOSIMENDAN FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS | Pharnext (FR) | 2021-03-31 | — | — | EP | disclosed |
| EP-3650021-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE | Pharnext (FR) | 2020-05-13 | — | — | EP | disclosed |
| EP-2496226-B1 | NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE | PHARNEXT (FR) | 2020-03-04 | — | — | EP | disclosed |
| EP-3031928-B1 | QUICK METHOD FOR DETECTING ENZYMES AND MICRO-ORGANISMS | BIO RAD INNOVATIONS (FR) | 2019-11-20 | — | — | EP | disclosed |
| US-9387206-B2 | Therapeutic approaches for treating Alzheimer's disease | PHARNEXT (FR) | 2016-07-12 | — | — | US | disclosed |
| EP-3031928-A1 | QUICK METHOD FOR DETECTING ENZYMES AND MICRO-ORGANISMS | Bio-Rad Innovations (FR) | 2016-06-15 | — | — | EP | disclosed |
| EP-2542688-B1 | QUICK METHOD FOR DETECTING ENZYMES AND MICRO-ORGANISMS | BIO RAD INNOVATIONS (FR) | 2016-05-11 | — | — | EP | disclosed |
| US-20150211044-A1 | QUICK METHOD FOR DETECTING ENYZMES AND MICROORGANISMS | BIO-RAD EUROPE GMBH (CH) | 2015-07-30 | — | — | US | disclosed |
| US-9012167-B2 | Quick method for detecting enzymes and microorganisms | BIO-RAD INNOVATIONS (FR) | 2015-04-21 | — | — | US | disclosed |
| US-20140357648-A1 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE | PHARNEXT (FR) | 2014-12-04 | — | — | US | disclosed |
| US-8809302-B2 | Therapeutic approaches for treating alzheimer'S disease | PHARNEXT (FR) | 2014-08-19 | — | — | US | disclosed |
| US-20130089883-A1 | QUICK METHOD FOR DETECTING ENYZMES AND MICROORANISMS | BIO-RAD INNOVATIONS (FR) | 2013-04-11 | — | — | US | disclosed |
| EP-2542688-A1 | QUICK METHOD FOR DETECTING ENZYMES AND MICRO-ORGANISMS | Bio-Rad Innovations (FR) | 2013-01-09 | — | — | EP | disclosed |
| CN-102834095-A | Novel therapy for the treatment of alzheimer's disease | PHARNEXT SAS | 2012-12-19 | — | — | CN | disclosed |
| US-20120270836-A1 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE | PHARNEXT (FR) | 2012-10-25 | — | — | US | disclosed |
| WO-2011107703-A1 | QUICK METHOD FOR DETECTING ENZYMES AND MICRO-ORGANISMS | BIO-RAD PASTEUR (FR) | 2011-09-09 | — | — | WO | disclosed |
| EP-2322163-A1 | New therapeutics approaches for treating alzheimer disease | Pharnext (FR) | 2011-05-18 | — | — | EP | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |