⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256529 | 1.00 | — | — | |
| SCHEMBL11495911 | 1.00 | — | — | |
| SCHEMBL24160898 | 0.71 | — | — | |
| SCHEMBL15771139 | 0.70 | — | — | |
| SCHEMBL309226 | 0.70 | — | — | |
| SCHEMBL15770544 | 0.70 | — | — | |
| SCHEMBL309227 | 0.70 | — | — | |
| SCHEMBL15770545 | 0.70 | — | — | |
| SCHEMBL309228 | 0.70 | — | — | |
| SCHEMBL359274 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924280-A | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-04-26 | — | — | CN | claimed |
| CN-115974784-B | Synthesis method of 4-fluoro-1H-pyrazole | 苏利制药科技江阴有限公司 | 2025-04-11 | — | — | CN | disclosed |
| US-20250059178-A1 | N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS | Aucentra Thereapeutics Pty LTD (AU) | 2025-02-20 | — | — | US | disclosed |
| CN-118217290-B | Use of soluble guanylate cyclase stimulators for the prevention and treatment of altitude pulmonary oedema | 中国人民解放军军事科学院军事医学研究院 | 2024-10-29 | — | — | CN | disclosed |
| CN-117924280-B | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-07-12 | — | — | CN | disclosed |
| CN-118217290-A | Use of soluble guanylate cyclase stimulators for the prevention and treatment of altitude pulmonary oedema | 中国人民解放军军事科学院军事医学研究院 | 2024-06-21 | — | — | CN | disclosed |
| US-11970491-B2 | N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amine derivatives as therapeutic compounds | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2024-04-30 | — | — | US | disclosed |
| CN-113461615-B | Preparation method of 4-fluoro-1H-pyrazole | 南京药石科技股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117924280-A | Substituted thienyl-5-fluoro-1H-pyrazolopyridine compound and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2024-04-26 | — | — | CN | disclosed |
| CN-115974784-A | Synthetic method of 4-fluoro-1H-pyrazole | 苏利制药科技江阴有限公司 | 2023-04-18 | — | — | CN | disclosed |
| EP-2611803-A1 | METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE | Bayer Pharma Aktiengesellschaft (DE) | 2013-07-10 | — | — | EP | disclosed |
| EP-2611802-A1 | BICYCLIC AZA HETEROCYCLES, AND USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| WO-2013043624-A1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013040790-A1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013030288-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012028647-A1 | BICYCLIC AZA HETEROCYCLES, AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028645-A1 | METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| US-4992592-A | 1-fluoro-1-halo-3,6-dioxabicyclo [4.1.0]heptane preparation, process and use | RHONE-POULENC CHIMIE (FR) | 1991-02-12 | — | — | US | disclosed |
| EP-0029282-B1 | PROCESS FOR PREPARING 5-HALOPYRIMIDINES AND 5-PYRIMIDINE METHANOLS | ELI LILLY AND COMPANY (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4239901-A | ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1980-12-16 | — | — | US | disclosed |