SCHEMBL256529

SCHEMBL256529

CN(C)/C=C(\F)C=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11495911 1.00
SCHEMBL165058 1.00
SCHEMBL24160898 0.71
SCHEMBL15771139 0.70
SCHEMBL309226 0.70
SCHEMBL15770544 0.70
SCHEMBL309227 0.70
SCHEMBL15770545 0.70
SCHEMBL309228 0.70
SCHEMBL359274 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3421470-B1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES IN CRYSTALLINE FORM ADVERIO PHARMA GMBH (DE) 2021-01-20 EP disclosed
US-10633356-B2 Hydrates of substituted 5-fluoro-1H-pyrazolopyridines ADVERIO PHARMA GMBH (DE) 2020-04-28 US disclosed
US-10633357-B2 Intermediates and process for preparing intermediates in the production of substituted pyrazolopyridines ADVERIO PHARMA GMBH (DE) 2020-04-28 US disclosed
US-10364229-B2 Crystalline substituted 5-fluoro-1H-pyrazolopyridines and process for preparing ADVERIO PHARMA GMBH (DE) 2019-07-30 US disclosed
US-20190177288-A1 INTERMEDIATES AND PROCESS FOR PREPARING INTERMEDIATES IN THE PRODUCTION OF SUBSTITUTED PYRAZOLOPYRIDINES ADVERIO PHARMA GMBH (DE) 2019-06-13 US disclosed
EP-3421470-A1 SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES IN CRYSTALLINE FORM Adverio Pharma GmbH (DE) 2019-01-02 EP disclosed
EP-2758059-B1 SUBSTITUTED PYRIMIDINES MERCK SHARP & DOHME (US) 2018-10-24 EP disclosed
EP-2782914-B1 METHOD FOR PRODUCING SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES ADVERIO PHARMA GMBH (DE) 2018-08-01 EP disclosed
US-20180065942-A1 CRYSTALLINE SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND PROCESS FOR PREPARING ADVERIO PHARMA GMBH (DE) 2018-03-08 US disclosed
US-20180065942-A1 CRYSTALLINE SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND PROCESS FOR PREPARING ADVERIO PHARMA GMBH (DE) 2018-03-08 US disclosed
WO-2013043624-A1 SUBSTITUTED PYRIMIDINES MERCK SHARP & DOHME CORP. (US) 2013-03-28 WO disclosed
WO-2013030288-A1 SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-03-07 WO disclosed
WO-2012004258-A9 RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-06-07 WO disclosed
WO-2012028647-A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-03-08 WO disclosed
WO-2012028645-A1 METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-03-08 WO disclosed
WO-2012004258-A1 RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2012-01-12 WO disclosed
US-7812022-B2 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors GLAXOSMITHKLINE LLC (US) 2010-10-12 US disclosed
US-20080051395-A1 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors SMITHKLINE BEECHAM CORPORATION 2008-02-28 US disclosed
US-4992592-A 1-fluoro-1-halo-3,6-dioxabicyclo [4.1.0]heptane preparation, process and use RHONE-POULENC CHIMIE (FR) 1991-02-12 US disclosed
EP-0029282-B1 PROCESS FOR PREPARING 5-HALOPYRIMIDINES AND 5-PYRIMIDINE METHANOLS ELI LILLY AND COMPANY (US) 1983-05-18 EP disclosed