Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16495393 | 0.99 | GCK (0.38) | GCKKCNH2GRM4ALKKMT2A | |
| SCHEMBL2668101 | 0.92 | GRM4 (0.37) | GCKGRM4ALKKMT2AALDH1A1 | |
| SCHEMBL2668191 | 0.83 | GRM4 (0.37) | GCKGRM4ALKKMT2AMEN1 | |
| SCHEMBL9072743 | 0.83 | GCK (0.38) | GCKGRM4KMT2AMEN1ALDH1A1 | |
| SCHEMBL2662227 | 0.82 | MEN1 (0.36) | GCKGRM4ALKKMT2AMEN1 | |
| SCHEMBL2668187 | 0.82 | ALDH1A1 (0.35) | GCKKMT2AMEN1ALDH1A1CHEK1 | |
| SCHEMBL2668188 | 0.82 | CHEK1 (0.35) | LRRK2CHEK1 | |
| SCHEMBL9072642 | 0.78 | JAK2 (0.40) | GCKGRM4KMT2AMEN1ALDH1A1 | |
| SCHEMBL2660466 | 0.76 | LRRK2 (0.49) | GCKKCNH2GRM4LRRK2 | |
| SCHEMBL2668239 | 0.75 | GCK (0.42) | GCKGRM4ALKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110301155-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301155-A1 | INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE | GCKR, GCK, KHK | GCK 2/4885KCNH2 437/4885GRM4 2714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.