Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | LOX | P28300 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12170342 | 0.87 | ALOX5AP (0.47) | BRD4BRD2PIK3CDPIK3CGCDK5 | |
| SCHEMBL10282726 | 0.86 | BRD4 (0.47) | BRD4BRD2PIK3CDPIK3CGCDK5 | |
| Hydrochloric Acid SCHEMBL1722419 | 0.86 | ALOX5AP (0.47) | BRD4BRD2PIK3CDPIK3CGCDK5 | |
| Hydrochloric Acid SCHEMBL1722423 | 0.86 | ALOX5AP (0.47) | BRD4BRD2PIK3CDPIK3CGCDK5 | |
| SCHEMBL12189159 | 0.84 | BRD4 (0.47) | BRD4BRD2CDK5CDK5R1LOX | |
| SCHEMBL4606376 | 0.80 | BRD4 (0.47) | BRD4BRD2PIK3CDPIK3CGCDK5 | |
| SCHEMBL5885963 | 0.79 | BRD4 (0.57) | BRD4BRD2TP53TSHRPSEN1 | |
| SCHEMBL5885959 | 0.79 | BRD4 (0.57) | BRD4BRD2TP53TSHRPSEN1 | |
| SCHEMBL6302770 | 0.79 | BRD4 (0.57) | BRD4BRD2TP53TSHRPSEN1 | |
| SCHEMBL10282718 | 0.79 | BRD4 (0.47) | BRD4BRD2NAMPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110312958-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312958-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | BRD4 1004/4885BRD2 1832/4885PIK3CD 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.