Edonentan

Edonentan

SCHEMBL1651069

Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 17/20 1.00
EDNRB P24530 18/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Edonentan SCHEMBL29742313 1.00 EDNRA (1.00) EDNRAEDNRB
SCHEMBL6641356 0.93 EDNRA (0.86) EDNRAEDNRB
SCHEMBL26041260 0.89 EDNRA (0.80) EDNRAEDNRB
SCHEMBL6641311 0.88 EDNRB (1.00) EDNRAEDNRB
SCHEMBL13668944 0.86 EDNRA (0.76) EDNRAEDNRB
SCHEMBL26552022 0.86 EDNRA (0.76) EDNRAEDNRB
SCHEMBL6703895 0.83 EDNRA (0.71) EDNRAEDNRB
SCHEMBL6641373 0.82 EDNRB (1.00) EDNRAEDNRB
SCHEMBL6963011 0.81 EDNRA (0.68) EDNRAEDNRB
SCHEMBL6641551 0.79 EDNRB (0.83) EDNRAEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260076948-A1 TREATMENT OF DIABETIC RETINOPATHY USING ENDOTHELIN RECEPTOR ANTAGONISTS PERFUSE THERAPEUTICS INC (US) 2026-03-19 US claimed
WO-2025137005-A1 METHODS OF PREPARING DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF OCULAR DISEASES PERFUSE THERAPEUTICS, INC. (US) 2025-06-26 WO claimed
WO-2025137007-A1 METHODS OF PREPARING DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF OCULAR DISEASES PERFUSE THERAPEUTICS, INC. (US) 2025-06-26 WO claimed
US-20250099435-A1 TREATMENT OF DIABETIC RETINOPATHY USING ENDOTHELIN RECEPTOR ANTAGONISTS PERFUSE THERAPEUTICS, INC. 2025-03-27 US claimed
WO-2024179362-A1 METHODS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION SKELETAL SEQUELAE THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2024-09-06 WO claimed
WO-2024141048-A1 METHODS FOR TREATING CORONAVIRUS INFECTIONS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2024-07-04 WO claimed
US-20240189288-A1 TREATMENT OF GLAUCOMA USING ENDOTHELIN RECEPTOR ANTAGONISTS PERFUSE THERAPEUTICS, INC. 2024-06-13 US claimed
EP-4329810-A1 TREATMENT OF OCULAR DISEASES USING ENDOTHELIN RECEPTOR ANTAGONISTS Perfuse Therapeutics, Inc. (US) 2024-03-06 EP claimed
US-20240058265-A1 TREATMENT OF OCULAR DISEASES USING ENDOTHELIN RECEPTOR ANTAGONISTS PERFUSE THERAPEUTICS, INC. 2024-02-22 US claimed
US-11738007-B2 Treatment of glaucoma using endothelin receptor antagonists PERFUSE THERAPEUTICS, INC. (US) 2023-08-29 US claimed
WO-2002049630-A2 METHOD FOR PREVENTING OR TREATING PAIN BY ADMINISTERING AN ENDOTHELIN ANTAGONIST BRISTOL-MYERS SQUIBB COMPANY (US) 2002-06-27 WO claimed
US-6313308-B1 CONTACTING BORONIC ACID-SUBSTITUTED BENZENESULFONIC ACID WITH HALOBENZENE IN PRESENCE OF PALLADIUM CATALYST AND ALKALI METAL COMPOUND BASE; SALT FORMATION, CHLORINATION, COUPLING BRISTOL-MYERS SQUIBB COMPANY 2001-11-06 US claimed
US-6268388-B1 ADMINISTERING A BIPHENYL SULFONAMIDE BRISTOL-MYERS SQUIBB COMPANY 2001-07-31 US claimed
WO-2001049289-A1 PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS TEXAS BIOTECHNOLOGY CORPORATION (US) 2001-07-12 WO claimed
EP-0996618-A4 ENDOTHELIN ANTAGONISTS: N- 2'- (4,5-DIMETHYL-3-ISOXAZOLYL) AMINO]SULFONYL]-4-(2-OXAZOLYL) 1,1'-BIPHENYL]-2-YL]METHYL] -N,3,3-TRIMETHYLBUTANAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL) -2'- (3,3-DIMETHYL-2-OXO-1-PYRROLIDINYL) METHYL] -4'-(2-OXAZOLYL) 1,1'-BIPHENYL]-2-SULFONAMIDE AND SALTS THEREOF BRISTOL MYERS SQUIBB CO (US) 2000-05-03 EP claimed
EP-0996618-A1 ENDOTHELIN ANTAGONISTS: N- 2'- (4,5-DIMETHYL-3-ISOXAZOLYL) AMINO]SULFONYL]-4-(2-OXAZOLYL) 1,1'-BIPHENYL]-2-YL]METHYL] -N,3,3-TRIMETHYLBUTANAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL) -2'- (3,3-DIMETHYL-2-OXO-1-PYRROLIDINYL) METHYL] -4'-(2-OXAZOLYL) 1,1'-BIPHENYL]-2-SULFONAMIDE AND SALTS THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-03 EP claimed
US-6043265-A TREATING HYPERTENSION, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MIGRAINE, UROGENITAL DISORDERS, ENDOTOXEMIA, ISCHEMIA, ATHEROSCLEROSIS, RESTENOSIS, SUBARACHNOID HEMORRHAGE, CONGESTIVE HEART FAILURE BRISTOL-MYERS SQUIBB CO. (US) 2000-03-28 US claimed
WO-1999010345-A1 METHOD FOR PREVENTING OR TREATING ERECTILE DYSFUNCTION BY ADMINISTERING AN ENDOTHELIN ANTAGONIST BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-04 WO claimed
WO-1998033780-A1 ENDOTHELIN ANTAGONISTS: N-[[2'-[ [(4,5-DIMETHYL-3-ISOXAZOLYL) AMINO]SULFONYL]-4-(2-OXAZOLYL) [1,1'-BIPHENYL]-2-YL]METHYL] -N,3,3-TRIMETHYLBUTANAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL) -2'-[(3,3-DIMETHYL-2-OXO-1-PYRROLIDINYL) METHYL] -4'-(2-OXAZOLYL)[1,1'-BIPHENYL]-2-SULFONAMIDE AND SALTS THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 1998-08-06 WO claimed
WO-1998033781-A1 METHOD FOR PREVENTING OR TREATING LOW RENIN HYPERTENSION BY ADMINISTERING AN ENDOTHELIN ANTAGONIST BRISTOL-MYERS SQUIBB COMPANY (US) 1998-08-06 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250099435-A1 TREATMENT OF DIABETIC RETINOPATHY USING ENDOTHELIN RECEPTOR ANTAGONISTS EDNRA, EDNRB, EDF1 EDNRA 1/4885EDNRB 2/4885
US-20240058265-A1 TREATMENT OF OCULAR DISEASES USING ENDOTHELIN RECEPTOR ANTAGONISTS EDNRA, EDNRB, ECE1 EDNRA 1/4885EDNRB 2/4885
US-20260076948-A1 TREATMENT OF DIABETIC RETINOPATHY USING ENDOTHELIN RECEPTOR ANTAGONISTS EDNRA, EDNRB, STRA6 EDNRA 1/4885EDNRB 2/4885
US-11738007-B2 Treatment of glaucoma using endothelin receptor antagonists EDNRA, EDNRB, FLT1 EDNRA 1/4885EDNRB 2/4885
US-20240189288-A1 TREATMENT OF GLAUCOMA USING ENDOTHELIN RECEPTOR ANTAGONISTS EDNRA, EDNRB, FLT1 EDNRA 1/4885EDNRB 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.