Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16511709 | 0.99 | MAPT (0.36) | MAPTPOLBKDM4EALDH1A1TP53 | |
| SCHEMBL16511897 | 0.87 | POLB (0.38) | MAPTPOLBKDM4EALDH1A1TP53 | |
| SCHEMBL16511711 | 0.86 | POLB (0.39) | MAPTPOLBKDM4EALDH1A1TP53 | |
| SCHEMBL16511693 | 0.85 | MAPT (0.37) | MAPTPOLBTP53THRBLMNA | |
| SCHEMBL16511967 | 0.85 | MAPT (0.35) | MAPTPOLBKDM4ETP53MEN1 | |
| SCHEMBL16511965 | 0.84 | MAPT (0.34) | MAPTPOLBTP53MEN1KMT2A | |
| SCHEMBL16511893 | 0.84 | MAPT (0.34) | MAPTPOLBALDH1A1TP53MEN1 | |
| SCHEMBL16511698 | 0.84 | MAPT (0.36) | MAPTPOLBTP53THRBLMNA | |
| SCHEMBL16511713 | 0.83 | MAPT (0.36) | MAPTPOLBTP53THRBLMNA | |
| SCHEMBL16511689 | 0.83 | MAPT (0.36) | MAPTPOLBTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011153865-A1 | 3-ORTHO-METHYLPHENYL-2-OXO-1-OXASPIRO[4,4]NON-3-EN-4-OL WITH BIOLOGICAL ACTIVITY, DERIVATIVES AND PREPARATION METHOD THEREOF | 湖南化工研究院 (CN) | 2011-12-15 | — | — | WO | disclosed |