Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 2/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | BMX | P51813 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16514634 | 0.91 | BRD4 (0.53) | BRD4JAK2SLC2A1FGFR4FGFR1 | |
| SCHEMBL16513654 | 0.83 | BTK (0.68) | JAK2FGFR1FGFR2SRCEGFR | |
| SCHEMBL29847942 | 0.83 | BTK (0.68) | JAK2FGFR1FGFR2SRCEGFR | |
| SCHEMBL16513811 | 0.83 | BRD4 (0.60) | BRD4JAK2SLC2A1FGFR4FGFR1 | |
| SCHEMBL16513994 | 0.82 | EGFR (0.63) | BRD4JAK2FGFR1FGFR2EGFR | |
| SCHEMBL16514597 | 0.80 | TTK (0.56) | BRD4JAK2FGFR1FGFR2SRC | |
| SCHEMBL19096959 | 0.79 | MAPK10 (0.55) | BRD4JAK2FGFR2EGFRBTK | |
| SCHEMBL93524 | 0.79 | MAP3K7 (0.57) | BRD4JAK2SLC2A1FGFR1SRC | |
| SCHEMBL93511 | 0.79 | EGFR (0.69) | BRD4JAK2SLC2A1EGFRBTK | |
| SCHEMBL16514973 | 0.79 | EGFR (0.52) | BRD4JAK2FGFR1FGFR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035936-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NeuPharma, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015027222-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. (US) | 2015-02-26 | — | — | WO | disclosed |