Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 5/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 6/20 | 0.48 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL93511 | 0.82 | EGFR (0.69) | MAP3K7MAP2K1SLC2A1BTKALK | |
| SCHEMBL93523 | 0.82 | MAP3K7 (0.74) | MAP3K7MAP2K1BTKMAPK1FGFR1 | |
| SCHEMBL30854787 | 0.82 | MAP3K7 (0.74) | MAP3K7MAP2K1BTKMAPK1FGFR1 | |
| SCHEMBL29352639 | 0.82 | MAP3K7 (0.74) | MAP3K7MAP2K1BTKMAPK1FGFR1 | |
| SCHEMBL16513550 | 0.79 | BRD4 (0.53) | MAP3K7MAP2K1SLC2A1BTKALK | |
| SCHEMBL16514634 | 0.74 | BRD4 (0.53) | SLC2A1BTKFGFR1JAK3EGFR | |
| SCHEMBL19970912 | 0.73 | EGFR (0.68) | MAP3K7MAP2K1BTKALKMAPK1 | |
| SCHEMBL16513811 | 0.72 | BRD4 (0.60) | SLC2A1BTKFGFR1EGFRJAK2 | |
| SCHEMBL16513994 | 0.72 | EGFR (0.63) | FGFR1JAK3EGFRJAK2BRD4 | |
| SCHEMBL10127876 | 0.71 | JAK3 (0.80) | BTKALKJAK3EGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2425830-A1 | Synergistic drug combination for the treatment of cancer | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2012-03-07 | — | — | EP | disclosed |