SCHEMBL16514030

SCHEMBL16514030

C=CC(=O)Nc1cccc(-c2nccc3cnc(Nc4ccc(N5CCN(CCO)CC5)cc4)nc23)c1

nearest known ligand 0.81

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FGFR2 P21802 3/20 0.81
FGFR1 P11362 3/20 0.66
KDR P35968 3/20 0.66
BTK Q06187 7/20 0.62
EGFR P00533 7/20 0.62
JAK3 P52333 6/20 0.57
JAK2 O60674 2/20 0.57
JAK1 P23458 2/20 0.57
TYK2 P29597 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16822908 0.93 FGFR2 (0.70) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16514332 0.92 FGFR2 (0.68) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16515148 0.91 FGFR2 (0.68) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16514468 0.91 BTK (0.75) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16513666 0.89 FGFR2 (1.00) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16515174 0.89 EGFR (0.65) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16514608 0.89 FGFR2 (0.64) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16514787 0.89 FGFR2 (0.64) FGFR2FGFR1KDRBTKEGFR
SCHEMBL16514250 0.88 BTK (0.75) FGFR2BTKEGFRJAK3JAK2
SCHEMBL16514299 0.88 EGFR (0.80) FGFR2FGFR1KDRBTKEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12403145-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC (US) 2025-09-02 US claimed
US-20240197752-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA INC 2024-06-20 US claimed
EP-3035936-B1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS NEUPHARMA INC (US) 2019-03-13 EP claimed
US-20150175601-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS NEUPHARMA, INC. 2015-06-25 US claimed
US-20260102406-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA INC (US) 2026-04-16 US disclosed
US-12403145-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC (US) 2025-09-02 US disclosed
US-20240197752-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA INC 2024-06-20 US disclosed
US-11865120-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC. (US) 2024-01-09 US disclosed
US-20220354864-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA, INC. 2022-11-10 US disclosed
US-11304957-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC. (US) 2022-04-19 US disclosed
US-20200306259-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA, INC. 2020-10-01 US disclosed
US-10653701-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC. (US) 2020-05-19 US disclosed
US-20180125855-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA, INC. 2018-05-10 US disclosed
US-9849139-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC. (US) 2017-12-26 US disclosed
US-20170196881-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY NEUPHARMA, INC. 2017-07-13 US disclosed
US-20170050936-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS NEUPHARMA, INC. 2017-02-23 US disclosed
US-9550770-B2 Substituted quinazolines for inhibiting kinase activity NEUPHARMA, INC. (US) 2017-01-24 US disclosed
EP-3035936-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS NeuPharma, Inc. (US) 2016-06-29 EP disclosed
US-20150175601-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS NEUPHARMA, INC. 2015-06-25 US disclosed
WO-2015027222-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS NEUPHARMA, INC. (US) 2015-02-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170196881-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-20240197752-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-11865120-B2 Substituted quinazolines for inhibiting kinase activity DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-20150175601-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS BRAF, PIK3CA, PLK1 FGFR2 365/4885FGFR1 441/4885KDR 1405/4885
US-12403145-B2 Substituted quinazolines for inhibiting kinase activity DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-20180125855-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-10653701-B2 Substituted quinazolines for inhibiting kinase activity DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-11304957-B2 Substituted quinazolines for inhibiting kinase activity DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-20200306259-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-20220354864-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY DCK, ABL1, MAP4K2 FGFR2 1364/4885FGFR1 1078/4885KDR 950/4885
US-20170050936-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CDK2, MAP3K6, MAP3K2 FGFR2 540/4885FGFR1 519/4885KDR 720/4885
US-20260102406-A1 SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY BRAF, TTK, MAP4K2 FGFR2 881/4885FGFR1 915/4885KDR 627/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.