Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 8/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.39 |
| ▸ | PIM1 | P11309 | 5/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16515549 | 1.00 | MAPT (0.40) | MAPTPIM3PIM2PIM1HRH3 | |
| SCHEMBL16515786 | 1.00 | MAPT (0.40) | MAPTPIM3PIM2PIM1HRH3 | |
| SCHEMBL15874969 | 0.93 | PIM2 (0.44) | MAPTPIM3PIM2PIM1KDM4E | |
| SCHEMBL15874967 | 0.93 | PIM2 (0.44) | MAPTPIM3PIM2PIM1KDM4E | |
| SCHEMBL16515417 | 0.88 | MAPT (0.41) | MAPTPIM3PIM2PIM1HRH3 | |
| SCHEMBL31302417 | 0.85 | KDM4E (0.40) | MAPTPIM3PIM2PIM1HRH3 | |
| SCHEMBL31302348 | 0.85 | KDM4E (0.40) | MAPTPIM3PIM2PIM1HRH3 | |
| SCHEMBL16515822 | 0.81 | PIM2 (0.40) | MAPTPIM3PIM2PIM1KDM4E | |
| SCHEMBL16515825 | 0.81 | PIM2 (0.40) | MAPTPIM3PIM2PIM1KDM4E | |
| SCHEMBL28822114 | 0.81 | MAPT (0.47) | MAPTHRH3KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036238-A1 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Corporation (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015027124-A1 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2015-02-26 | — | — | WO | disclosed |