Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 15/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 5/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16515825 | 1.00 | PIM2 (0.40) | PIM2GAAMAPTKDM4EALDH1A1 | |
| SCHEMBL15875738 | 0.83 | MAPT (0.43) | PIM2GAAMAPTALDH1A1PIM1 | |
| SCHEMBL17254425 | 0.83 | MAPT (0.43) | PIM2GAAMAPTALDH1A1PIM1 | |
| SCHEMBL17254424 | 0.83 | MAPT (0.43) | PIM2GAAMAPTALDH1A1PIM1 | |
| SCHEMBL15875059 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3 | |
| SCHEMBL15875056 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3 | |
| SCHEMBL16525750 | 0.82 | MAPT (0.49) | PIM2GAAMAPTPIM1PIM3 | |
| SCHEMBL16515786 | 0.81 | MAPT (0.40) | PIM2GAAMAPTKDM4EALDH1A1 | |
| SCHEMBL16515549 | 0.81 | MAPT (0.40) | PIM2GAAMAPTKDM4EALDH1A1 | |
| SCHEMBL16515552 | 0.81 | MAPT (0.40) | PIM2GAAMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196244-A1 | PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| EP-3036238-A1 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Corporation (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2016010897-A1 | BICYCLIC HETEROAROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2016-01-21 | — | — | WO | disclosed |
| WO-2015027124-A1 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2015-02-26 | — | — | WO | disclosed |