Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16517304 | 0.91 | RARG (0.48) | MAP3K14RARGKDM4EALDH1A1RPA1 | |
| SCHEMBL16516697 | 0.87 | ELANE (0.46) | MAP3K14RPA1CNR2ELANE | |
| SCHEMBL16516420 | 0.82 | MAP3K14 (0.43) | MAP3K14KDM4EALDH1A1RPA1ELANE | |
| SCHEMBL16517137 | 0.81 | STAT1 (0.49) | MAP3K14RARGKDM4EALDH1A1RPA1 | |
| SCHEMBL24977692 | 0.81 | MAP3K14 (0.50) | MAP3K14CA1CA2STAT1 | |
| SCHEMBL29949344 | 0.81 | MAP3K14 (0.50) | MAP3K14CA1CA2STAT1 | |
| SCHEMBL16517765 | 0.79 | RPA1 (0.56) | MAP3K14KDM4EALDH1A1RPA1CNR2 | |
| SCHEMBL16517631 | 0.78 | ELANE (0.51) | MAP3K14RARGRPA1CNR2ELANE | |
| SCHEMBL16516889 | 0.75 | MAP3K14 (0.45) | MAP3K14KDM4EALDH1A1RPA1CNR2 | |
| SCHEMBL16517091 | 0.75 | MAP3K14 (0.45) | MAP3K14KDM4EALDH1A1RPA1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036230-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015025025-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |