Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 1/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16516764 | 0.89 | ELANE (0.53) | RARGMAP3K14ELANEMAPK14RPA1 | |
| SCHEMBL16517426 | 0.82 | ELANE (0.57) | RARGELANESMN1; SMN2RPA1ALDH1A1 | |
| SCHEMBL16517055 | 0.80 | SCN9A (0.44) | MAP3K14ELANESMN1; SMN2RPA1STAT1 | |
| SCHEMBL16516840 | 0.80 | RPA1 (0.56) | MAP3K14ELANESMN1; SMN2RPA1KMT2A | |
| SCHEMBL16517137 | 0.80 | STAT1 (0.49) | RARGMAP3K14SMN1; SMN2RPA1STAT1 | |
| SCHEMBL16517038 | 0.79 | MAP3K14 (0.44) | MAP3K14ELANESMN1; SMN2RPA1STAT1 | |
| SCHEMBL16516686 | 0.79 | MAP3K14 (0.47) | MAP3K14ELANESMN1; SMN2RPA1STAT1 | |
| SCHEMBL16517373 | 0.78 | MAPT (0.41) | ELANEMAPK14SMN1; SMN2RPA1STAT1 | |
| SCHEMBL16517695 | 0.78 | ALDH1A1 (0.40) | MAP3K14ELANESMN1; SMN2RPA1STAT1 | |
| SCHEMBL16517004 | 0.78 | ALDH1A1 (0.41) | ELANESMN1; SMN2RPA1STAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036230-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015025025-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |