Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.63 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518202 | 0.90 | PTGDR2 (0.51) | HTR5AMKNK1PTGDR2 | |
| SCHEMBL16518213 | 0.89 | HTR5A (0.63) | HTR5AMKNK1ESR2RORCPTGDR2 | |
| SCHEMBL16518219 | 0.88 | HTR5A (0.48) | HTR5AMKNK1ESR2RORCPTGDR2 | |
| SCHEMBL16518233 | 0.88 | HTR5A (0.48) | HTR5AMKNK1ESR2PTGDR2NR1H2 | |
| SCHEMBL16518218 | 0.85 | HTR5A (0.49) | HTR5AMKNK1ESR2RORCPTGDR2 | |
| SCHEMBL16518214 | 0.84 | HTR5A (0.51) | HTR5AMKNK1ESR2RORCPTGDR2 | |
| SCHEMBL16518220 | 0.82 | HTR5A (0.52) | HTR5AMKNK1ESR2RORCPTGDR2 | |
| SCHEMBL16518216 | 0.82 | PTGDR2 (0.49) | HTR5AMKNK1ESR2PTGDR2NR1H2 | |
| SCHEMBL16518221 | 0.82 | HTR5A (0.47) | HTR5AMKNK1ESR2RORCPTGDR2 | |
| SCHEMBL16518750 | 0.81 | PTGDR2 (0.49) | HTR5AMKNK1RORCPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |