Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.69 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1652104 | 0.93 | PTGDR2 (0.71) | PTGDR2TBXA2RPTGDRALDH1A1MAPT | |
| SCHEMBL8737655 | 0.92 | PTGDR2 (0.69) | PTGDR2TBXA2RPTGDRNR1H4RAB9A | |
| SCHEMBL15746418 | 0.91 | PTGDR2 (0.71) | PTGDR2TBXA2RPTGDRNR1H4KDM4E | |
| SCHEMBL1654290 | 0.91 | PTGDR2 (0.68) | PTGDR2TBXA2RPTGDRNR1H4RAB9A | |
| SCHEMBL1652434 | 0.90 | PTGDR2 (0.66) | PTGDR2TBXA2RPTGDRALDH1A1MAPT | |
| SCHEMBL1652340 | 0.90 | PTGDR2 (0.87) | PTGDR2TBXA2RPTGDRNR1H4 | |
| SCHEMBL8738714 | 0.89 | PTGDR2 (0.65) | PTGDR2TBXA2RPTGDRALDH1A1MAPT | |
| SCHEMBL1652387 | 0.89 | PTGDR2 (0.65) | PTGDR2TBXA2RPTGDRMAPTRAB9A | |
| SCHEMBL1652371 | 0.88 | PTGDR2 (0.64) | PTGDR2TBXA2RPTGDRNR1H4KDM4E | |
| SCHEMBL8738078 | 0.88 | PTGDR2 (0.64) | PTGDR2TBXA2RPTGDRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | claimed |
| JP-4671955-B2 | — | — | 2011-04-20 | — | — | JP | claimed |
| US-20100322980-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | GB005, INC. | 2010-12-23 | — | — | US | claimed |
| US-7812160-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | claimed |
| US-20070129355-A1 | G-protein-coupled chemoattractant receptor, expressed on T helper cells antagonists such as [4-(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)-5-pyrimidinyl]acetic acid;, used for the treatment of allergic diseases, inflammatory diseases, eosinophil- and basophil-related diseases | ACTIMIS PHARMACEUTICALS, INC. (US) | 2007-06-07 | — | — | US | claimed |
| JP-2006524645-A | — | — | 2006-11-02 | — | — | JP | claimed |
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | claimed |
| EP-1471057-B1 | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2006-01-18 | — | — | EP | claimed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | claimed |
| EP-1471057-A1 | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 | Bayer HealthCare AG (DE) | 2004-10-27 | — | — | EP | claimed |
| WO-2014079806-A1 | PYRIMIDINE COMPOUNDS FOR TREATING HAIRLOSS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-30 | — | — | WO | disclosed |
| US-20140148470-A1 | PYRIMIDINE COMPOUNDS FOR TREATING HAIRLOSS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20140148470-A1 | PYRIMIDINE COMPOUNDS FOR TREATING HAIRLOSS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20120129820-A1 | NEW PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20120129820-A1 | NEW PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20070129355-A1 | G-protein-coupled chemoattractant receptor, expressed on T helper cells antagonists such as [4-(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)-5-pyrimidinyl]acetic acid;, used for the treatment of allergic diseases, inflammatory diseases, eosinophil- and basophil-related diseases | ACTIMIS PHARMACEUTICALS, INC. (US) | 2007-06-07 | — | — | US | disclosed |
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| EP-1471057-B1 | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| EP-1471057-A1 | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 | Bayer HealthCare AG (DE) | 2004-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129355-A1 | G-protein-coupled chemoattractant receptor, expressed on T helper cells antagonists such as [4-(dimethylamino)-2-(4-{[4-(trifluoromethyl)benzoyl]amino}benzyl)-5-pyrimidinyl]acetic acid;, used for the treatment of allergic diseases, inflammatory diseases, eosinophil- and basophil-related diseases | HRH2, HRH1, HRH4 | PTGDR2 78/4885TBXA2R 48/4885PTGDR 81/4885 |
| US-20100322980-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | HRH2, HRH1, CXCR2 | PTGDR2 73/4885TBXA2R 60/4885PTGDR 111/4885 |
| US-20140148470-A1 | PYRIMIDINE COMPOUNDS FOR TREATING HAIRLOSS | TYMS, TYMP, DHFR | PTGDR2 1511/4885TBXA2R 945/4885PTGDR 1386/4885 |
| US-20120129820-A1 | NEW PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | HRH2, HRH1, HRH4 | PTGDR2 11/4885TBXA2R 20/4885PTGDR 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.