Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triptorelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR known ✓ | P30968 | 3/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.74 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.66 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.59 |
| ▸ | APLNR | P35414 | 1/20 | 0.54 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.54 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triptorelin SCHEMBL16815056 | 1.00 | PTGS1 (0.74) | PTGS1GNRHRABCC2C5AR1APLNR | |
| Triptorelin SCHEMBL1371630 | 1.00 | PTGS1 (0.74) | PTGS1GNRHRABCC2C5AR1APLNR | |
| Triptorelin SCHEMBL5079698 | 1.00 | PTGS1 (0.74) | PTGS1GNRHRABCC2C5AR1APLNR | |
| Triptorelin SCHEMBL22289009 | 1.00 | PTGS1 (0.74) | PTGS1GNRHRABCC2C5AR1APLNR | |
| SCHEMBL11678163 | 0.99 | PTGS1 (0.73) | PTGS1GNRHRABCC2C5AR1APLNR | |
| Triptorelin SCHEMBL29459903 | 0.99 | PTGS1 (0.72) | PTGS1GNRHRABCC2C5AR1APLNR | |
| SCHEMBL29373920 | 0.98 | PTGS1 (0.72) | PTGS1GNRHRABCC2C5AR1CXCR4 | |
| SCHEMBL29914777 | 0.98 | PTGS1 (0.72) | PTGS1GNRHRABCC2C5AR1APLNR | |
| SCHEMBL1319486 | 0.98 | PTGS1 (0.71) | PTGS1GNRHRABCC2C5AR1APLNR | |
| Gonadorelin SCHEMBL143114 | 0.98 | PTGS1 (0.71) | PTGS1GNRHRABCC2C5AR1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4593953-A1 | INHIBITION OF LUTEINIZING HORMONE (LH) ACTION AS TREATMENT OF PERIMENOPAUSAL AND POSTMENOPAUSAL SYMPTOMS AND COMPLICATIONS | Rigshospitalet (DK) | 2025-08-06 | — | — | EP | claimed |
| WO-2024068968-A1 | INHIBITION OF LUTEINIZING HORMONE (LH) ACTION AS TREATMENT OF PERIMENOPAUSAL AND POSTMENOPAUSAL SYMPTOMS AND COMPLICATIONS | RIGSHOSPITALET (DK) | 2024-04-04 | — | — | WO | claimed |
| US-20100323963-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2010-12-23 | — | — | US | claimed |
| US-20100317580-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2010-12-16 | — | — | US | claimed |
| CN-101578287-A | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazoles derivatives, process for their preparation and their use | AETERMA ZENTARIS GMBH (DE) | 2009-11-11 | — | — | CN | claimed |
| EP-2066679-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AEterna Zentaris GmbH (DE) | 2009-06-10 | — | — | EP | claimed |
| US-20080090758-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2008-04-17 | — | — | US | claimed |
| EP-1900742-A1 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof | AEterna Zentaris GmbH (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008028934-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2008-03-13 | — | — | WO | claimed |
| EP-4746850-A1 | EXTENDED RELEASE DRUG-LOADED MICROPARTICLES | Ferring BV (NL) | 2026-05-27 | — | — | EP | disclosed |
| EP-4593953-A1 | INHIBITION OF LUTEINIZING HORMONE (LH) ACTION AS TREATMENT OF PERIMENOPAUSAL AND POSTMENOPAUSAL SYMPTOMS AND COMPLICATIONS | Rigshospitalet (DK) | 2025-08-06 | — | — | EP | disclosed |
| WO-2025017533-A1 | EXTENDED RELEASE DRUG-LOADED MICROPARTICLES | FERRING B.V. (NL) | 2025-01-23 | — | — | WO | disclosed |
| WO-2024068968-A1 | INHIBITION OF LUTEINIZING HORMONE (LH) ACTION AS TREATMENT OF PERIMENOPAUSAL AND POSTMENOPAUSAL SYMPTOMS AND COMPLICATIONS | RIGSHOSPITALET (DK) | 2024-04-04 | — | — | WO | disclosed |
| CN-108837143-B | Application of triptorelin | 南华大学 | 2022-03-01 | — | — | CN | disclosed |
| US-7741277-B2 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof | AETERNA ZENTARIS GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| CN-101578287-A | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazoles derivatives, process for their preparation and their use | AETERMA ZENTARIS GMBH (DE) | 2009-11-11 | — | — | CN | disclosed |
| EP-2066679-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AEterna Zentaris GmbH (DE) | 2009-06-10 | — | — | EP | disclosed |
| US-20080090758-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2008-04-17 | — | — | US | disclosed |
| EP-1900742-A1 | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof | AEterna Zentaris GmbH (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008028934-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100323963-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | EPCAM, CD99, PTMS | GNRHR 1196/4885PTGS1 4556/4885ABCC2 1937/4885 |
| US-20100317580-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | EPCAM, CD99, PTMS | GNRHR 1196/4885PTGS1 4556/4885ABCC2 1937/4885 |
| US-20080090758-A1 | CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF | EPCAM, CD99, PTMS | GNRHR 1196/4885PTGS1 4556/4885ABCC2 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.