Triptorelin

SCHEMBL29459903

CC(=O)O.CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GNRHR

The experimentally established mechanism targets of Triptorelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	GNRHR known ✓	P30968	3/20	0.66

▸	PTGS1	P23219	1/20	0.72

▸	ABCC2	Q92887	1/20	0.69

▸	C5AR1	P21730	1/20	0.58

▸	KISS1R	Q969F8	1/20	0.55

▸	APLNR	P35414	2/20	0.54

▸	CXCR4	P61073	2/20	0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL11678163	0.99	PTGS1 (0.73)	PTGS1ABCC2GNRHRC5AR1KISS1R
Triptorelin SCHEMBL22289009	0.99	PTGS1 (0.74)	PTGS1ABCC2GNRHRC5AR1KISS1R
Triptorelin SCHEMBL1652722	0.99	PTGS1 (0.74)	PTGS1ABCC2GNRHRC5AR1KISS1R
Triptorelin SCHEMBL16815056	0.99	PTGS1 (0.74)	PTGS1ABCC2GNRHRC5AR1KISS1R
Triptorelin SCHEMBL1371630	0.99	PTGS1 (0.74)	PTGS1ABCC2GNRHRC5AR1KISS1R
Triptorelin SCHEMBL5079698	0.99	PTGS1 (0.74)	PTGS1ABCC2GNRHRC5AR1KISS1R
Gonadorelin SCHEMBL29459914	0.98	PTGS1 (0.70)	PTGS1ABCC2GNRHRC5AR1APLNR
SCHEMBL29373920	0.97	PTGS1 (0.72)	PTGS1ABCC2GNRHRC5AR1CXCR4
SCHEMBL29914777	0.97	PTGS1 (0.72)	PTGS1ABCC2GNRHRC5AR1APLNR
Acetic Acid SCHEMBL166006	0.97	PTGS1 (0.68)	PTGS1ABCC2GNRHRC5AR1KISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-11975048-B2	Long-acting fatty acid-conjugated GnRH derivatives and pharmaceutical compositions containing same	NOVEL PHARMA INC. (KR)	2024-05-07	—	—	US	disclosed
US-20220054593-A1	LONG-ACTING FATTY ACID-CONJUGATED GnRH DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME	NOVEL PHARMA INC. (KR)	2022-02-24	—	—	US	disclosed