Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16517515 | 0.91 | MAP3K14 (0.47) | MAP3K14MPOSTAT1ALDH1A1KMT2A | |
| SCHEMBL16516970 | 0.87 | MAP3K14 (0.47) | MAP3K14PLK1STAT1ALDH1A1KMT2A | |
| SCHEMBL16532535 | 0.81 | MAP3K14 (0.47) | MAP3K14MPOALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL16516996 | 0.81 | MAP3K14 (0.57) | MAP3K14MPOSMN1; SMN2RAB9A | |
| SCHEMBL16516642 | 0.80 | ALDH1A1 (0.47) | MAP3K14MPOSTAT1ALDH1A1KMT2A | |
| SCHEMBL16517675 | 0.79 | MAP3K14 (0.48) | MAP3K14MPOSTAT1ALDH1A1KMT2A | |
| SCHEMBL16517506 | 0.78 | MAP3K14 (0.45) | MAP3K14MPOSTAT1ALDH1A1KMT2A | |
| SCHEMBL16516710 | 0.78 | MAP3K14 (0.43) | MAP3K14MPOSTAT1ALDH1A1MAPK1 | |
| SCHEMBL16516700 | 0.77 | STAT1 (0.49) | MAP3K14MPOSTAT1ALDH1A1MAPK1 | |
| SCHEMBL16517472 | 0.77 | MAP3K14 (0.57) | MAP3K14SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015025025-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |