SCHEMBL16539076

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL16539079	1.00	TNFRSF1A (0.62)	TNFRSF1AMEN1KMT2AABCG2ABCB1
	SCHEMBL18671601	0.92	TNFRSF1A (0.52)	TNFRSF1AMEN1KMT2AABCG2ABCB1
	SCHEMBL16539425	0.91	TNFRSF1A (0.55)	TNFRSF1AMEN1KMT2AABCG2ABCB1
	SCHEMBL16539424	0.91	TNFRSF1A (0.55)	TNFRSF1AMEN1KMT2AABCG2ABCB1
	SCHEMBL16539126	0.90	ABCG2 (0.57)	TNFRSF1AABCG2ABCB1KRASTUBB1
	SCHEMBL16539128	0.90	ABCG2 (0.57)	TNFRSF1AABCG2ABCB1KRASTUBB1
	SCHEMBL17924168	0.90	KRAS (0.56)	TNFRSF1AMEN1KMT2AABCG2ABCB1
	SCHEMBL16547775	0.90	KRAS (0.56)	TNFRSF1AMEN1KMT2AABCG2ABCB1
	SCHEMBL17924234	0.89	ABCG2 (0.53)	TNFRSF1AABCG2ABCB1KRASLMNA
	SCHEMBL16547629	0.89	KRAS (0.57)	TNFRSF1AABCG2ABCB1ALDH1A1KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.