FOXO3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Piplartine (SCHEMBL173092)	1.00	1/20
Piplartine (SCHEMBL2465593)	1.00	1/20
(Z)-Piplartine (SCHEMBL30013548)	1.00	1/20
SCHEMBL12675623	0.87	1/20
SCHEMBL15422557	0.87	1/20
SCHEMBL15422559	0.87	1/20
SCHEMBL173090	0.83	1/20
SCHEMBL173088	0.82	1/20
SCHEMBL25283508	0.82	1/20
SCHEMBL19295194	0.80	1/20
SCHEMBL25243729	0.80	1/20
SCHEMBL25283503	0.80	1/20
SCHEMBL173087	0.78	1/20
SCHEMBL98524	0.77	1/20
SCHEMBL17472036	0.77	1/20
SCHEMBL23727840	0.77	1/20
SCHEMBL30140770	0.77	1/20
SCHEMBL15444232	0.77	1/20
SCHEMBL98536	0.76	1/20
SCHEMBL98534	0.75	1/20

Clinical trials — most relevant to FOXO3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Prevention of Autogenous Vein Graft Failure in Coronary Artery Bypass Procedures	PHASE3	COMPLETED
Blood Flow Restriction Training in Chronic Heart Failure: an Effective Training Strategy?	PHASE2	COMPLETED
Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome	PHASE2	COMPLETED
Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Oral Nitrite for Older Heart Failure Patients	PHASE2	COMPLETED
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
Can Dormant Perimenopausal Ovarian Follicles Become FSH Responsive?	nan	UNKNOWN
Expression of Longevity Genes in Response to Extended Fasting	nan	COMPLETED
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
FoxO3a and PU.1 in Acute Lymphoblastic Leukemia	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Follicular Fluid microRNAs in Ovarian Aging and Reproduction	nan	RECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities	nan	RECRUITING
Effect of Total Knee Arthroplasty on Sarcopenia in Patients With Osteoarthritis in the Knee	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Immune Interactions in Severe Asthma	nan	COMPLETED
Relation Between NAFLD and BM DENSITY	nan	NOT_YET_RECRUITING
The Effects Grapes on Health Indices	nan	COMPLETED
The Influence of Daily Grapes Intake on Sarcopenia in Postmenopausal Women	nan	COMPLETED
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone.	nan	COMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals	nan	COMPLETED
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FOXO3 binder may also engage these)

Protein	Name	Similarity
Q9WVH4	—	1.000	Q9WVH4 →
Q6EUW1	—	1.000	Q6EUW1 →
Q810W5	—	1.000	Q810W5 →
G3V7R4	—	1.000	G3V7R4 →
Q9R1E0	—	1.000	Q9R1E0 →
Q6EUW2	—	1.000	Q6EUW2 →
FOXO1	Forkhead box protein O1	1.000	landscape →
A3RK74	—	1.000	A3RK74 →
Q66JJ0	—	1.000	Q66JJ0 →
A3RK75	—	1.000	A3RK75 →
E1BPQ1	—	1.000	E1BPQ1 →
A4L7N3	—	0.999	A4L7N3 →
Q68F77	—	0.995	Q68F77 →
Q8R5I7	—	0.995	Q8R5I7 →
P78337	—	0.995	P78337 →
B3LYS5	—	0.994	B3LYS5 →
B4KBF6	—	0.994	B4KBF6 →
B4JSC2	—	0.994	B4JSC2 →
P40645	—	0.994	P40645 →
Q9PVZ3	—	0.994	Q9PVZ3 →
Q96NZ1	—	0.994	Q96NZ1 →
Q95V55	—	0.994	Q95V55 →
Q28EM1	—	0.994	Q28EM1 →
Q6ZPI3	—	0.993	Q6ZPI3 →
Q6YHU8	—	0.993	Q6YHU8 →
P35582	—	0.993	P35582 →
Q5RCU4	—	0.993	Q5RCU4 →
Q9DE25	—	0.993	Q9DE25 →
F1QDF8	—	0.993	F1QDF8 →
P40647	—	0.993	P40647 →