Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16539300 | 1.00 | TNFRSF1A (0.52) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16539243 | 0.92 | MAPT (0.56) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16539248 | 0.92 | MAPT (0.56) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL17930352 | 0.91 | TNFRSF1A (0.54) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16539252 | 0.90 | TNFRSF1A (0.56) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16539259 | 0.90 | TNFRSF1A (0.56) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16539443 | 0.87 | MAPT (0.55) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16539440 | 0.87 | MAPT (0.55) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16538963 | 0.87 | TNFRSF1A (0.55) | TNFRSF1AMAPTPOLBLMNAMEN1 | |
| SCHEMBL16538966 | 0.87 | TNFRSF1A (0.55) | TNFRSF1AMAPTPOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3039013-B1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2018-09-12 | — | — | EP | disclosed |
| US-9604933-B2 | Pyrazolochalcones as potential anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-03-28 | — | — | US | disclosed |
| US-9604933-B2 | Pyrazolochalcones as potential anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-03-28 | — | — | US | disclosed |
| US-20160207888-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-21 | — | — | US | disclosed |
| US-20160207888-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-21 | — | — | US | disclosed |
| EP-3039013-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | Council of Scientific and Industrial Research (IN) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015029051-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-03-05 | — | — | WO | disclosed |
| WO-2015029051-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207888-A1 | PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS | HCCS, CCNE2, FOXO3 | TNFRSF1A 2780/4885MAPT 4760/4885POLB 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.