Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17939844 | 0.85 | PPARG (0.37) | HSD17B1HSD17B2MTNR1AMTNR1BMEN1 | |
| SCHEMBL16548134 | 0.85 | PPARG (0.37) | HSD17B1HSD17B2MTNR1AMTNR1BMEN1 | |
| SCHEMBL16540409 | 0.81 | PLA2G1B (0.37) | MEN1KMT2AKDM4EALDH1A1TDP1 | |
| SCHEMBL17939841 | 0.80 | CASR (0.40) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL16548150 | 0.80 | CASR (0.40) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL18609947 | 0.79 | HSD17B1 (0.35) | HSD17B1HSD17B2MEN1KMT2AKDM4E | |
| SCHEMBL17939912 | 0.78 | CASR (0.40) | MEN1KMT2ATDP1 | |
| SCHEMBL17939866 | 0.78 | CASR (0.38) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL16548177 | 0.78 | CASR (0.38) | MTNR1AMTNR1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL16540251 | 0.77 | KCNH2 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3039014-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | Lupin Atlantis Holdings SA (CH) | 2016-07-06 | — | — | EP | claimed |
| WO-2015028938-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-03-05 | — | — | WO | claimed |
| EP-3039014-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | Lupin Atlantis Holdings SA (CH) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015028938-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-03-05 | — | — | WO | disclosed |