Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12777876 | 0.71 | CYP2A6 (0.36) | CSF1RALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1653139 | 0.71 | MAP2 (0.53) | MAP2CSF1R | |
| SCHEMBL1654834 | 0.67 | CYP2A6 (0.33) | MAP2CSF1RMEN1KMT2ACYP2A6 | |
| SCHEMBL1654838 | 0.67 | CYP2A6 (0.32) | CSF1RCYP2A6 | |
| SCHEMBL13098625 | 0.64 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPTNPSR1RXFP1 | |
| SCHEMBL1653145 | 0.63 | BRD4 (0.48) | ALDH1A1L3MBTL1 | |
| SCHEMBL1636841 | 0.63 | TP53 (0.48) | ALDH1A1HPGDMAPTNPSR1KMT2A | |
| SCHEMBL30345966 | 0.60 | AURKA (0.52) | MAP2CA1CA2CA12CA3 | |
| SCHEMBL432457 | 0.60 | AURKA (0.52) | MAP2CA1CA2CA12CA3 | |
| SCHEMBL1652825 | 0.59 | KDM4E (0.40) | MAOACA1CA2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486010-B1 | ESTROGEN RECEPTOR LIGANDS | KARO PHARMA AB (SE) | 2019-06-12 | — | — | EP | disclosed |
| EP-2486010-B1 | ESTROGEN RECEPTOR LIGANDS | KARO PHARMA AB (SE) | 2019-06-12 | — | — | EP | disclosed |
| US-8710243-B2 | Estrogen receptor ligands | KARO BIO AB (SE) | 2014-04-29 | — | — | US | disclosed |
| EP-2486010-A2 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-15 | — | — | EP | disclosed |
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-09 | — | — | US | disclosed |
| WO-2011042473-A2 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202861-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | ESR1, ESRRA, GPER1 | MAP2 4425/4885MAOA 3961/4885CA1 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.