Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.48 |
| ▸ | METAP1 | P53582 | 3/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16543598 | 0.81 | PRKCI (0.41) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL4725361 | 0.79 | KDM4E (0.55) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL17427076 | 0.78 | KDM4E (0.57) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL30776779 | 0.76 | KDM4E (0.55) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL13581443 | 0.76 | KDM4E (0.55) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL15216238 | 0.76 | KDM4E (0.51) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL14823128 | 0.76 | NPC1 (0.53) | METAP2NPC1CTNNB1WNT3APOLB | |
| SCHEMBL23080058 | 0.75 | KDM4E (0.58) | CBFBMETAP1METAP2KDM4ENPC1 | |
| SCHEMBL7085431 | 0.74 | NPC1 (0.61) | KDM4ENPC1PKMRAB9ACTNNB1 | |
| SCHEMBL14823134 | 0.72 | CYP11B1 (0.53) | NPC1RAB9ASMN1; SMN2TP53TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150065487-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2015-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065487-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | CBFB 196/4885METAP1 1936/4885METAP2 1756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.