Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 14/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 7/20 | 0.47 |
| ▸ | PRKACA | P17612 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | GSK3A | P49840 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | PRKX | P51817 | 5/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.47 |
| ▸ | PRKCG | P05129 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | AKT2 | P31751 | 4/20 | 0.47 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16540267 | 0.99 | ROCK1 (0.46) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| SCHEMBL16548114 | 0.90 | GPR139 (0.42) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| SCHEMBL16540252 | 0.89 | ROCK1 (0.45) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| Hydrochloric Acid SCHEMBL17939944 | 0.89 | GPR139 (0.41) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| SCHEMBL17945886 | 0.88 | PFKFB3 (0.43) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| SCHEMBL16548165 | 0.88 | ROCK1 (0.47) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| SCHEMBL17945114 | 0.88 | PFKFB3 (0.43) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| Hydrochloric Acid SCHEMBL16540435 | 0.88 | PFKFB3 (0.42) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| Hydrochloric Acid SCHEMBL16540143 | 0.88 | ROCK1 (0.47) | ROCK1ROCK2PRKG1PRKACACYP3A4 | |
| SCHEMBL16548321 | 0.87 | ROCK1 (0.44) | ROCK1ROCK2PRKG1PRKACACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| US-20160214924-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-07-28 | — | — | US | disclosed |
| US-20160214924-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-07-28 | — | — | US | disclosed |
| WO-2015028938-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214924-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, RYR1 | ROCK1 2574/4885ROCK2 2986/4885PRKG1 2114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.