Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16540116 | 1.00 | PTGS2 (0.37) | PTGS2PFKFB3PRKACAGSK3AGSK3B | |
| SCHEMBL17939832 | 0.95 | PTGS2 (0.38) | PTGS2PFKFB3PRKACAGSK3AGSK3B | |
| SCHEMBL17945543 | 0.95 | PTGS2 (0.38) | PTGS2PFKFB3PRKACAGSK3AGSK3B | |
| SCHEMBL16548310 | 0.94 | CASR (0.38) | PRKACAGSK3AGSK3BPRKXROCK1 | |
| SCHEMBL17939887 | 0.94 | CASR (0.38) | PRKACAGSK3AGSK3BPRKXROCK1 | |
| SCHEMBL17945975 | 0.92 | PTGS2 (0.40) | PTGS2PDE1APDE1BPDE1CLMNA | |
| SCHEMBL18215373 | 0.92 | PTGS2 (0.40) | PTGS2PDE1APDE1BPDE1CLMNA | |
| Hydrochloric Acid SCHEMBL17939874 | 0.92 | PTGS2 (0.39) | PTGS2PDE1APDE1BPDE1CLMNA | |
| SCHEMBL17939843 | 0.91 | TACR3 (0.32) | PPARGTACR3 | |
| SCHEMBL16548247 | 0.91 | TACR3 (0.32) | PPARGTACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| WO-2015028938-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-03-05 | — | — | WO | disclosed |