SCHEMBL16551027

SCHEMBL16551027

O=S(=O)(c1ccc2ccccc2c1)c1ccc2oc3c(c2c1)CCNC3

nearest known ligand 0.85

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 20/20 0.85
KCNH2 Q12809 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10323891 0.92 HTR6 (1.00) HTR6
Hydrochloric Acid SCHEMBL10323742 0.91 HTR6 (0.98) HTR6
SCHEMBL16550868 0.89 HTR6 (1.00) HTR6KCNH2
SCHEMBL16551190 0.85 HTR6 (0.86) HTR6KCNH2
SCHEMBL16551078 0.85 HTR6 (0.83) HTR6KCNH2
SCHEMBL16551158 0.83 HTR6 (0.84) HTR6KCNH2
SCHEMBL16551259 0.83 HTR6 (0.84) HTR6KCNH2
SCHEMBL16550814 0.83 HTR6 (0.84) HTR6KCNH2
SCHEMBL16551260 0.83 HTR6 (0.75) HTR6KCNH2
SCHEMBL16550942 0.83 HTR6 (0.75) HTR6KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516445-B1 TRICYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS CEPHALON INC (US) 2015-03-11 EP disclosed