Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 19/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16554814 | 1.00 | CNR2 (1.00) | CNR2ALDH1A1LMNAPOLBGAA | |
| SCHEMBL14911897 | 0.84 | CNR2 (0.72) | CNR2 | |
| SCHEMBL14911900 | 0.84 | CNR2 (0.72) | CNR2 | |
| SCHEMBL14912129 | 0.84 | CNR2 (0.72) | CNR2 | |
| SCHEMBL16554610 | 0.79 | CNR2 (1.00) | CNR2ALDH1A1GAA | |
| SCHEMBL16554453 | 0.79 | CNR2 (1.00) | CNR2ALDH1A1GAA | |
| SCHEMBL16554450 | 0.79 | CNR2 (1.00) | CNR2ALDH1A1GAA | |
| SCHEMBL16554870 | 0.79 | CNR2 (0.71) | CNR2ALDH1A1 | |
| SCHEMBL16554754 | 0.79 | CNR2 (0.71) | CNR2ALDH1A1 | |
| SCHEMBL16554756 | 0.79 | CNR2 (0.71) | CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3483163-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2021-06-23 | — | — | EP | claimed |
| EP-3483163-A2 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2019-05-15 | — | — | EP | claimed |
| US-9593123-B2 | Triazolo[4,5-D]pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-03-14 | — | — | US | claimed |
| EP-3041843-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-13 | — | — | EP | claimed |
| US-20160168158-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-06-16 | — | — | US | claimed |
| WO-2015032769-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-12 | — | — | WO | claimed |
| EP-3943497-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2022-01-26 | — | — | EP | disclosed |
| EP-3483163-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2021-06-23 | — | — | EP | disclosed |
| EP-3483163-A2 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2019-05-15 | — | — | EP | disclosed |
| EP-3041843-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2019-01-02 | — | — | EP | disclosed |
| US-9593123-B2 | Triazolo[4,5-D]pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593123-B2 | Triazolo[4,5-D]pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593123-B2 | Triazolo[4,5-D]pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-03-14 | — | — | US | disclosed |
| EP-3041843-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-13 | — | — | EP | disclosed |
| US-20160168158-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168158-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168158-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-06-16 | — | — | US | disclosed |
| WO-2015032769-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168158-A1 | NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | TYMS, TYMP, P2RX4 | CNR2 285/4885ALDH1A1 724/4885LMNA 4369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.