Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 16/20 | 0.36 |
| ▸ | TPH2 | Q8IWU9 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16555256 | 1.00 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21486089 | 0.90 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16555188 | 0.90 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16567382 | 0.86 | MAPT (0.46) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL30558980 | 0.86 | MAPT (0.46) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16567092 | 0.85 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL30559116 | 0.85 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL23627347 | 0.84 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16567701 | 0.84 | GAA (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21486021 | 0.84 | GAA (0.44) | MAPTRAB9AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041842-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | Karos Pharmaceuticals, Inc. (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2015035113-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-03-12 | — | — | WO | disclosed |