Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 13/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TPH2 | Q8IWU9 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | CCKAR | P32238 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16555188 | 1.00 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16555256 | 0.90 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL16555346 | 0.90 | MAPT (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL609424 | 0.85 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL609423 | 0.85 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL611761 | 0.84 | KDM4E (0.44) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL30559122 | 0.81 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL611248 | 0.81 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL611249 | 0.81 | MAPT (0.45) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL30558980 | 0.78 | MAPT (0.46) | MAPTRAB9AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041842-B1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS INC (US) | 2019-10-23 | — | — | EP | disclosed |