SCHEMBL16555652

SCHEMBL16555652

CC1CCc2c(S(=O)(=O)C(F)F)ccc(F)c21

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPAS1 Q99814 18/20 0.43
VEGFA P15692 6/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15445106 0.75 DRD2 (0.35)
SCHEMBL13948432 0.75 DRD2 (0.35)
SCHEMBL16556035 0.73 EPAS1 (0.41) EPAS1VEGFA
SCHEMBL16555759 0.73 EPAS1 (0.63) EPAS1VEGFA
SCHEMBL18036735 0.73 EPAS1 (0.63) EPAS1VEGFA
SCHEMBL16555560 0.72 EPAS1 (0.64) EPAS1VEGFA
SCHEMBL28634264 0.72 EPAS1 (0.76) EPAS1VEGFA
SCHEMBL16555662 0.71 EPAS1 (0.57) EPAS1VEGFA
SCHEMBL23691473 0.71 SLC6A2 (0.30)
SCHEMBL16555875 0.70 EPAS1 (0.65) EPAS1VEGFA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3043784-A1 ARYL ETHERS AND USES THEREOF Peloton Therapeutics, Inc. (US) 2016-07-20 EP disclosed
WO-2015035223-A1 ARYL ETHERS AND USES THEREOF PELOTON THERAPEUTICS, INC. (US) 2015-03-12 WO disclosed