Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | IL1RN | P18510 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | PTGIR | P43119 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944761 | 0.77 | EPAS1 (0.35) | EPAS1IL1RNERAP2ERAP1CYP1A2 | |
| SCHEMBL15021689 | 0.77 | EPAS1 (0.35) | EPAS1IL1RNERAP2ERAP1CYP1A2 | |
| SCHEMBL15262548 | 0.77 | EPAS1 (0.35) | EPAS1IL1RNERAP2ERAP1CYP1A2 | |
| SCHEMBL30239732 | 0.74 | IL1RN (0.50) | EPAS1IL1RNERAP2ERAP1 | |
| SCHEMBL20185074 | 0.74 | IL1RN (0.50) | EPAS1IL1RNERAP2ERAP1 | |
| SCHEMBL23987304 | 0.73 | ADRA2A (0.39) | EPAS1 | |
| SCHEMBL18036895 | 0.70 | EPAS1 (0.37) | EPAS1 | |
| SCHEMBL18036897 | 0.70 | EPAS1 (0.37) | EPAS1 | |
| SCHEMBL16556241 | 0.70 | EPAS1 (0.37) | EPAS1 | |
| SCHEMBL21585257 | 0.69 | IL1RN (0.31) | IL1RNERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3043784-A1 | ARYL ETHERS AND USES THEREOF | Peloton Therapeutics, Inc. (US) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015035223-A1 | ARYL ETHERS AND USES THEREOF | PELOTON THERAPEUTICS, INC. (US) | 2015-03-12 | — | — | WO | disclosed |