Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 3/20 | 0.32 |
| ▸ | PDE1A | P54750 | 3/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18027461 | 0.86 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DDPP4 | |
| SCHEMBL14090807 | 0.85 | KDM4E (0.40) | PDE4APDE4BPDE4CPDE4DSOS1 | |
| SCHEMBL14850177 | 0.71 | EGFR (0.40) | PDE4APDE4BPDE4CPDE4DFGFR1 | |
| SCHEMBL16558015 | 0.70 | TNF (0.45) | PDE4APDE4BPDE4CPDE4DFGFR1 | |
| SCHEMBL16281253 | 0.70 | KDM4E (0.50) | PDE4APDE4BPDE4CPDE4DSOS1 | |
| SCHEMBL16558014 | 0.69 | HTT (0.46) | PDE4APDE4BPDE4CPDE4DFGFR1 | |
| SCHEMBL20609572 | 0.68 | ALDH1A1 (0.41) | PDE3BPDE3AKDM4EPDE10A | |
| SCHEMBL16156475 | 0.68 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DDPP4 | |
| SCHEMBL18561590 | 0.67 | HTR2A (0.47) | PDE4APDE4BPDE4CPDE4DPDCD1 | |
| SCHEMBL13696616 | 0.65 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353126-B2 | Substituted triazoles useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150072959-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | MIDCAP FINANCIAL TRUST | 2015-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072959-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, MERTK | PDE4A 1910/4885PDE4B 1781/4885PDE4C 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.