Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165665 | 0.97 | HRH3 (0.43) | HRH3RAD52RECQLGRM5DRD3 | |
| SCHEMBL176068 | 0.88 | HRH3 (0.35) | HRH3SMN1; SMN2 | |
| SCHEMBL175797 | 0.86 | HRH3 (0.40) | HRH3DRD3 | |
| SCHEMBL15738855 | 0.80 | NPC1 (0.48) | HRH3GRM5NPC1RAB9A | |
| SCHEMBL15738751 | 0.79 | NPC1 (0.46) | HRH3GRM5NPC1RAB9A | |
| SCHEMBL12474148 | 0.77 | NPC1 (0.46) | HRH3GRM5NPC1RAB9A | |
| SCHEMBL166435 | 0.77 | HRH3 (0.33) | HRH3 | |
| SCHEMBL166290 | 0.77 | NPC1 (0.43) | HRH3GRM5NPC1RAB9A | |
| SCHEMBL164398 | 0.76 | HRH3 (0.34) | HRH3 | |
| SCHEMBL17156957 | 0.75 | HRH3 (0.42) | HRH3GRM5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611444-A1 | HETEROCYCLYL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS | Suven Life Sciences Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029070-A1 | HETEROCYCLYL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |