Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.35 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.35 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.35 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19473213 | 0.92 | MEN1 (0.39) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL19473217 | 0.90 | MEN1 (0.38) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL13367680 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL13341003 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL13117381 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL12248445 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL12248450 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL14978150 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 | |
| SCHEMBL15341350 | 0.90 | LGALS9 (0.36) | PTPN1TDP1LGALS9LGALS1LGALS3 | |
| SCHEMBL15344331 | 0.90 | PTPN1 (0.47) | MEN1USP2POLBKMT2APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376591-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2016-12-29 | — | — | US | disclosed |
| US-9476045-B2 | iRNA agents with biocleavable tethers | ALNYLAM PHARMACEUTICALS, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20150073133-A1 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS | BANK OF AMERICA, N.A. | 2015-03-12 | — | — | US | disclosed |