LGALS9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3278668	0.54	10/20
SCHEMBL3284428	0.54	10/20
SCHEMBL3284431	0.51	10/20
SCHEMBL2430521	1.00	9/20
SCHEMBL2430523	1.00	9/20
SCHEMBL3276516	0.54	9/20
SCHEMBL1425152	1.00	8/20
SCHEMBL2432165	1.00	8/20
SCHEMBL2432167	1.00	8/20
SCHEMBL3277373	1.00	8/20
SCHEMBL3278173	0.86	8/20
SCHEMBL3276985	0.86	8/20
SCHEMBL2432200	0.74	8/20
SCHEMBL2432203	0.74	8/20
SCHEMBL2432865	0.69	8/20
SCHEMBL2432867	0.69	8/20
SCHEMBL2431042	0.66	8/20
SCHEMBL2431045	0.66	8/20
SCHEMBL3278577	0.66	8/20
SCHEMBL2429950	0.64	8/20

Clinical trials — most relevant to LGALS9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Radiotherapy to Patients With CA19-9-elevated Advanced Pancreatic Cancer	PHASE3	RECRUITING
A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease	PHASE2	COMPLETED
A Phase 2b Study of GCS-100 in Patients With Chronic Kidney Disease Caused by Diabetes	PHASE2	UNKNOWN
A Phase 2 Extension Study of Study GCS-100-CS-4002	PHASE2	COMPLETED
Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction	PHASE2	UNKNOWN
mFOLFIRINOX Plus Radiotherapy to Patients With CA19-9-normal Advanced Pancreatic Cancer	PHASE2	RECRUITING
Effect of Modified Citrus Pectin on PSA Kinetics in Biochemical Relapsed PC With Serial Increases in PSA	PHASE2	COMPLETED
GR-MD-02 Plus Pembrolizumab in Melanoma, Non-small Cell Lung Cancer, and Squamous Cell Head and Neck Cancer Patients	PHASE1	COMPLETED
Evaluation of Serum Galectin-9 Level in Systemic Lupus Erythematosus Patients and it's Association With Disease Activity and Organ Damage	nan	UNKNOWN
The Diagnostic Value of Serum Oncostatin M and Galactin 3 as Biomarkers in Diagnosis of Ulcerative Colitis Disease	nan	NOT_YET_RECRUITING
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis	nan	UNKNOWN
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies	nan	COMPLETED
Urinary G3BP as a Novel Biomarker in Lupus Nephritis	nan	NOT_YET_RECRUITING
Galectin-3 Binding Protein in Cardiovascular Disease and Chronic Heart Failure	nan	COMPLETED
An Exosomal miRNA-based Liquid Biopsy for ICC Detection	nan	COMPLETED
Galectin and Respiratory Weaning	nan	UNKNOWN
Galectin-3 in Septic and Non-septic Acute Kidney Injury	nan	UNKNOWN
Galectin-3 for Thromboembolic Formation in Patients With Atrial Fibrillation CHA₂DS₂-VASc Scoring	nan	UNKNOWN
Effect of Low-Glycemic Index Mediterranean Diet on AGEs	nan	COMPLETED
Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer	nan	NOT_YET_RECRUITING
Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter	nan	COMPLETED
Association of CD49d and CD44 in CLL Patients and Their Role in Prognosis	nan	UNKNOWN
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia	nan	UNKNOWN
Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients	nan	UNKNOWN
Biomarkers for Risk Stratification After STEMI	nan	UNKNOWN
PDAC Peripheral and Portal Vein Sampling	nan	COMPLETED
Forecasting Occult liveR Metastasis Using an Exosomal Signature for Intelligent Guided Hepatic Targeting	nan	COMPLETED
Galectin-3 in Patients With Endometriosis	nan	UNKNOWN
Galectin-3 as a Biomarker in Patients With Chagas Disease	nan	COMPLETED
KIDney Injury in Times of COVID-19 (KIDCOV)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a LGALS9 binder may also engage these)

Protein	Name	Similarity
Q6DKI2	—	1.000	Q6DKI2 →
Q3B8N2	—	1.000	Q3B8N2 →
Q3MHZ8	—	0.995	Q3MHZ8 →
P97840	—	0.993	P97840 →
O08573	—	0.990	O08573 →
LGALS4	Galectin-4	0.978	landscape →
Q29058	—	0.978	Q29058 →
O54891	—	0.977	O54891 →
P47967	—	0.975	P47967 →
Q3T0D6	—	0.971	Q3T0D6 →
Q8K419	—	0.971	Q8K419 →
P38552	—	0.971	P38552 →
LGALS8	Galectin-8	0.959	landscape →
P07583	—	0.957	P07583 →
Q62665	—	0.955	Q62665 →
Q5R7M1	—	0.955	Q5R7M1 →
Q9JL15	—	0.955	Q9JL15 →
C0HJQ1	—	0.954	C0HJQ1 →
LGALS3	Galectin-3	0.954	landscape →
P97590	—	0.953	P97590 →
P81184	—	0.952	P81184 →
C0HJR3	—	0.951	C0HJR3 →
P47953	—	0.951	P47953 →
P47845	—	0.949	P47845 →
P11762	—	0.949	P11762 →
P48538	—	0.948	P48538 →
Q9Z144	—	0.947	Q9Z144 →
P16110	—	0.946	P16110 →
P11116	—	0.946	P11116 →
Q49I35	—	0.946	Q49I35 →