Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16561918 | 0.85 | UPP1 (1.00) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL11121714 | 0.83 | UPP1 (0.69) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL6625526 | 0.80 | UPP1 (0.66) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL9114384 | 0.79 | UPP1 (0.60) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL5182348 | 0.79 | UPP1 (0.64) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL6655303 | 0.78 | UPP1 (0.68) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL8941878 | 0.77 | UPP1 (0.61) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL8025123 | 0.76 | UPP1 (0.64) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL16561913 | 0.73 | UPP1 (1.00) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL8901518 | 0.73 | UPP1 (0.61) | UPP1ALDH1A1CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9700547-B2 | Use of 6-hydroxy-2-pyridones and derivatives thereof for preparing a pharmaceutical composition that acts by inhibiting the human uridine phosphorylase enzyme | UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS (BR) | 2017-07-11 | — | — | US | disclosed |
| EP-3042657-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UNIÃO BRASILEIRA DE EDUCAÇAO E ASSISTÊNCIA- MANTENEDORA DA PUCRS (BR) | 2016-07-13 | — | — | EP | disclosed |
| US-20160193197-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS (BR) | 2016-07-07 | — | — | US | disclosed |
| WO-2015031968-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS (BR) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193197-A1 | USE OF 6-HYDROXY-2-PYRIDONES AND DERIVATIVES THEREOF FOR PREPARING A PHARMACEUTICAL COMPOSITION THAT ACTS BY INHIBITING THE HUMAN URIDINE PHOSPHORYLASE ENZYME | UPP1, PNP, TYMP | UPP1 1/4885ALDH1A1 515/4885CYP2C9 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.