SCHEMBL8901518

SCHEMBL8901518

Cc1c(O)[nH]c(=O)c(C#N)c1C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UPP1 Q16831 5/20 0.61
KDM4E B2RXH2 7/20 0.53
ATM Q13315 2/20 0.53
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
MAPT P10636 2/20 0.42
LMNA P02545 1/20 0.42
ALDH1A1 P00352 4/20 0.42
GAA P10253 3/20 0.41
GLA P06280 2/20 0.40
HPGD P15428 2/20 0.40
TP53 P04637 1/20 0.40
PHGDH O43175 1/20 0.39
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HSD17B10 Q99714 1/20 0.38
USP2 O75604 1/20 0.37
RAB9A P51151 1/20 0.37
MCL1 Q07820 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1086023 0.83 UPP1 (0.53) UPP1KDM4EATMKMT2AMEN1
SCHEMBL11493834 0.82 UPP1 (0.55) UPP1KDM4EATMKMT2AMEN1
SCHEMBL11496948 0.80 UPP1 (0.53) UPP1KDM4EATMKMT2AMEN1
SCHEMBL11121714 0.80 UPP1 (0.69) UPP1KDM4EATMKMT2AMEN1
SCHEMBL11051571 0.80 UPP1 (0.56) UPP1KDM4EATMKMT2AMEN1
SCHEMBL11835926 0.80 UPP1 (0.49) UPP1KDM4EATMKMT2AMEN1
SCHEMBL3797196 0.78 KDM4E (0.68) UPP1KDM4EATMALDH1A1GAA
SCHEMBL6655303 0.78 UPP1 (0.68) UPP1KDM4EATMKMT2AMEN1
SCHEMBL22890710 0.78 UPP1 (0.48) UPP1KDM4EATMKMT2AMEN1
SCHEMBL16561913 0.77 UPP1 (1.00) UPP1KDM4EATMKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552790-B2 Positive modulators of the muscarinic acetylcholine receptor M4 VANDERBILT UNIVERSITY (US) 2026-02-17 US disclosed
US-20260035366-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 UNIV VANDERBILT (US) 2026-02-05 US disclosed
US-12448380-B2 Positive modulators of the muscarinic acetylcholine receptor M4 VANDERBILT UNIVERSITY (US) 2025-10-21 US disclosed
US-12344608-B2 Positive modulators of the muscarinic acetylcholine receptor M4 VANDERBILT UNIVERSITY (US) 2025-07-01 US disclosed
US-20250136600-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-05-01 US disclosed
US-20250122199-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250122201-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250122198-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250122200-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250011320-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-01-09 US disclosed
WO-2017112719-A1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME CORP. (US) 2017-06-29 WO disclosed
US-20170183342-A1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME LLC 2017-06-29 US disclosed
US-7371831-B2 Polyazo, disazo, trisazo, triazine, hair and cationic dyes CLARIANT FINANCE (BVI) LIMITED (VG) 2008-05-13 US disclosed
US-7371831-B2 Polyazo, disazo, trisazo, triazine, hair and cationic dyes CLARIANT FINANCE (BVI) LIMITED (VG) 2008-05-13 US disclosed
EP-0799260-A1 PROCESS FOR PREPARING DYED MELAMINE-FORMALDEHYDE CONDENSATION PRODUCTS BASF AKTIENGESELLSCHAFT (DE) 1997-10-08 EP disclosed
WO-1996020229-A1 PROCESS FOR PREPARING DYED MELAMINE-FORMALDEHYDE CONDENSATION PRODUCTS BASF AKTIENGESELLSCHAFT (DE) 1996-07-04 WO disclosed
EP-0104876-B1 HERBICIDAL CYCLOHEXANE-1,3-DIONE DERIVATIVES ICI AUSTRALIA LIMITED (AU) 1991-12-27 EP disclosed
US-4631081-A Herbicidal cyclohexane-1,3-dione derivatives ICI AUSTRALIA LIMITED (AU) 1986-12-23 US disclosed
EP-0142863-A2 Reactive pyridone azo dyestuffs MITSUBISHI KASEI CORPORATION (JP) 1985-05-29 EP disclosed
EP-0104876-A2 Herbicidal cyclohexane-1,3-dione derivatives ICI AUSTRALIA LIMITED (AU) 1984-04-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122200-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-20170183342-A1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR CHRM5, CHRM4, CHRM1 UPP1 3563/4885KDM4E 1436/4885ATM 3648/4885
US-12552790-B2 Positive modulators of the muscarinic acetylcholine receptor M4 CHRM4, CHRM1, CHRM5 UPP1 3915/4885KDM4E 437/4885ATM 2560/4885
US-20250011320-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-20250136600-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-20250122201-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-12344608-B2 Positive modulators of the muscarinic acetylcholine receptor M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-20250122198-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-20250122199-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885
US-20260035366-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM3, CHRM5 UPP1 4476/4885KDM4E 775/4885ATM 1692/4885
US-12448380-B2 Positive modulators of the muscarinic acetylcholine receptor M4 CHRM4, CHRM1, CHRM3 UPP1 2460/4885KDM4E 753/4885ATM 2220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.