Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 20/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.68 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16564677 | 1.00 | RORC (0.72) | RORCNR1I2NR1H3 | |
| SCHEMBL16564682 | 1.00 | RORC (0.72) | RORCNR1I2NR1H3 | |
| SCHEMBL18197140 | 0.91 | RORC (0.61) | RORCNR1I2NR1H3 | |
| SCHEMBL18013076 | 0.91 | RORC (0.61) | RORCNR1I2NR1H3 | |
| SCHEMBL16586583 | 0.86 | RORC (0.79) | RORCNR1I2NR1H3 | |
| SCHEMBL16564696 | 0.86 | RORC (0.79) | RORCNR1I2NR1H3 | |
| SCHEMBL18896616 | 0.85 | RORC (0.87) | RORC | |
| SCHEMBL16553718 | 0.85 | RORC (0.87) | RORC | |
| SCHEMBL18896617 | 0.85 | RORC (0.87) | RORC | |
| SCHEMBL16553681 | 0.85 | RORC (0.82) | RORCNR1I2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046906-B1 | ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2015042212-A1 | RORγ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2015035278-A1 | RORγ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-12 | — | — | WO | disclosed |