Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.52 |
| ▸ | CCND3 | P30281 | 11/20 | 0.52 |
| ▸ | CCND1 | P24385 | 7/20 | 0.52 |
| ▸ | CCND2 | P30279 | 6/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CCNH | P51946 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16570797 | 0.90 | WEE1 (0.54) | CDK4CCND3CCND1CCND2FGFR1 | |
| SCHEMBL16570214 | 0.88 | FGFR4 (0.51) | CDK4CCND3CCND1CCND2FGFR4 | |
| SCHEMBL16570589 | 0.85 | FGFR4 (0.59) | FGFR4JAK2BRD4JAK1BRD2 | |
| SCHEMBL16570263 | 0.83 | JAK2 (0.49) | CDK4CCND3CCND1CCND2FGFR1 | |
| SCHEMBL16580851 | 0.80 | FGFR4 (0.57) | FGFR4JAK2BRD4JAK1BRD2 | |
| SCHEMBL16570179 | 0.78 | FGFR4 (0.56) | FGFR4JAK2BRD4JAK1BRD2 | |
| SCHEMBL16570959 | 0.78 | FGFR4 (0.59) | CDK4CCND1FGFR4CCNA2CDK2 | |
| SCHEMBL16570057 | 0.78 | JAK2 (0.49) | FGFR4JAK2BRD4WEE1JAK1 | |
| SCHEMBL16570240 | 0.77 | MARK3 (0.47) | CDK4CCND1CDK6CDK1CCNB1 | |
| SCHEMBL16580757 | 0.77 | RPS6KA6 (0.45) | CDK4CCND3CCND1CCND2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2016-08-04 | — | — | US | claimed |
| WO-2015038417-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | claimed |
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2016-08-04 | — | — | US | disclosed |
| US-20150175545-A1 | Preparation Method of Fluoro-Substituted Deuterated Diphenylurea | SUZHOU ZELGEN BIOPHARMACEUTICAL CO LTD (CN) | 2015-06-25 | — | — | US | disclosed |
| WO-2015038417-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | SRC, PTK2, FYN | CDK4 243/4885CCND3 1198/4885CCND1 1029/4885 |
| US-20150175545-A1 | Preparation Method of Fluoro-Substituted Deuterated Diphenylurea | CCND3, UBE2D3, VDR | CDK4 49/4885CCND3 1/4885CCND1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.