Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 4/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.36 |
| ▸ | CCNC | P24863 | 4/20 | 0.36 |
| ▸ | CDK8 | P49336 | 4/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571392 | 0.87 | PTPN11 (0.42) | XDHSLC22A12CCNCCDK8NUDT1 | |
| SCHEMBL16571390 | 0.87 | CCNC (0.47) | XDHSLC22A12CCNCCDK8MYC | |
| SCHEMBL16571057 | 0.85 | PARP1 (0.39) | XDHSLC22A12MYCCYP2C8CYP2C9 | |
| SCHEMBL16571358 | 0.85 | XDH (0.41) | XDHSLC22A12CYP2C8CYP2C9 | |
| SCHEMBL16571181 | 0.85 | CCNC (0.51) | XDHSLC22A12CCNCCDK8CDC7 | |
| SCHEMBL16571739 | 0.82 | XDH (0.40) | XDHSLC22A12CYP2C8CYP2C9 | |
| SCHEMBL16571180 | 0.81 | SLC22A12 (0.42) | XDHSLC22A12CCNCCDK8MYC | |
| SCHEMBL16571862 | 0.80 | XDH (0.35) | XDHSLC22A12CYP2C8CYP2C9 | |
| SCHEMBL16571686 | 0.80 | XDH (0.39) | XDHSLC22A12CCNCCDK8CYP2C8 | |
| SCHEMBL16571044 | 0.80 | MPL (0.39) | XDHSLC22A12CCNCCDK8CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | claimed |
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |