Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 11/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155681 | 0.81 | IL2 (0.47) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL12156050 | 0.79 | SMN1; SMN2 (0.52) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL12241731 | 0.79 | SMN1; SMN2 (0.47) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL12156320 | 0.78 | SMN1; SMN2 (0.51) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL12155776 | 0.78 | SMN1; SMN2 (0.51) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL12241592 | 0.78 | SMN1; SMN2 (0.52) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL16572273 | 0.77 | IL2 (0.47) | IL2SMN1; SMN2NPC1ALDH1A1TP53 | |
| SCHEMBL12241576 | 0.76 | SMN1; SMN2 (0.49) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL12241671 | 0.76 | IL2 (0.51) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL1701611 | 0.76 | STIM1 (0.65) | IL2SMN1; SMN2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980629-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980629-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-03-17 | — | — | US | disclosed |