Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | RBBP5 | Q15291 | 5/20 | 0.65 |
| ▸ | DPY30 | Q9C005 | 5/20 | 0.65 |
| ▸ | ASH2L | Q9UBL3 | 5/20 | 0.65 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.37 |
| ▸ | GRB2 | P62993 | 7/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16572497 | 1.00 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL16572501 | 1.00 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL16572496 | 1.00 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL16572494 | 1.00 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL16572498 | 1.00 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL16572502 | 1.00 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004660 | 0.92 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004662 | 0.92 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004655 | 0.92 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15005648 | 0.92 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980838-B2 | Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |