Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 1.00 |
| ▸ | AR | P10275 | 12/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12998942 | 1.00 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL12942951 | 1.00 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL16572795 | 1.00 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL12998909 | 0.90 | PGR (0.81) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL12942958 | 0.87 | PGR (0.77) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL13768720 | 0.85 | PGR (0.73) | PGRARLMNAABCB11NR3C1 | |
| SCHEMBL12942954 | 0.85 | AR (1.00) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL16572805 | 0.85 | AR (1.00) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL12998963 | 0.85 | PGR (1.00) | PGRARLMNAABCC4ABCB11 | |
| SCHEMBL16572820 | 0.85 | AR (1.00) | PGRARLMNAABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238149-B1 | 19-NOR-STEROID DERIVATIVES WITH A 15ALPHA, 16ALPHA-METHYLENE GROUP AND A SATURATED 17,17-SPIROLACTONE RING, USE THEREOF, AND MEDICAMENTS CONTAINING SAID DERIVATIVES | BAYER IP GMBH (DE) | 2015-03-18 | — | — | EP | disclosed |